| 09/2001–08/2007 | Doctorate Student, Organic Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, China, Supervisor: Prof. Haiping Xia |
| 09/1997-07/2001 | Undergraduate Student, Material Science, College of Chemistry and Chemical Engineering, Xiamen University, China, Supervisor: Prof. Haiping Xia |
09/2007–08/2011 | Assistant Professor, Organic Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, China |
04/2012–04/2013 | Postdoctoral Fellow, Computational Chemistry, Department of Chemistry, The Hong Kong University of Science& Technology, Hong Kong, Supervisor: Prof. Zhenyang Lin |
08/2011–08/2018 | Associate Professor, Organic Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, China |
08/2019–08/2020 | Visiting Scholar, Theoretical organic and inorganic chemistry, Department of Chemistry and Biochemistry, University of California，Los Angeles, In collaboration with Prof. Kendall N. Houk |
08/2018– present | Professor, Organic Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, China |
The State Natural Science Award (the Second Prize, 2020, the Second Accomplisher)
The Top-Notch Young Talents Program of Fujian Province
Thieme Chemistry Journals Award (2019)
Natural Science Award of Fujian Province (the First Prize, 2018, the Second Accomplisher)
Program for New Century Excellent Talents in Fujian Province University (2018)
Teaching Contest for University Young Teachers of Fujian Province (the First Prize, 2014)
71. Zhao, J.; Cai, Y.; Yang, X.; Zhang, H.* Heavier Group 14 Congeners of Metalla-isobenzenes: Access to Metalla-isosilabenzene and Metalla-isogermabenzene by One-Pot Reactions. Chin. J. Chem. 2024, 42, 1121-1127.
70. Lin, Z.; Yan, Z.; Cai, Y.; Xuan, J.; He, N.; Zhang, H.* Reactions of Ruthenabenzene with Propynols Involving Hydrogen-Bonding-Induced [2 + 2] Cycloaddition. Organometallics. 2023. 42, 1615−1620
69. Lin, Z.;† Cai, Y.;† Zhang, Y.; Zhang, H.;* Xia, H.* Heterocyclic Suzuki–Miyaura coupling reaction of metalla-aromatics and mechanistic analysis of site selectivity. Chem. Sci. 2023,14, 1227-1233.(Lin and Cai contributed equally to this work.)
68. Huang, F.; Yan, Z.; Zheng, X.; Cai, Y.; Zhang, H.;* Xia, H.* One-pot Synthesis of High-Strained Metal Vinylidene and Metal Carbyne. Chem. - Eur. J. 2022, 28, e202201229.
67. Zhang, H.;* Thogersen, M. K.; Jamieson, C. S.; Xue, X.-S.; Jorgensen, K. A.;* Houk, K.* Ambimodal Transition States in Diels-Alder Cycloadditions of Tropolone and Tropolonate with N-Methylmaleimide. Angew. Chem. Int. Ed. 2021, 60, 24991-24996.
66. Cai, Y.;† Hua, Y.;† Lu, Z.; Lan, Q.; Lin, Z.; Fei, J.; Chen, Z.; Zhang, H.;* Xia, H.* Electrophilic aromatic substitution reactions of compounds with Craig-Mobius aromaticity. Proc. Natl. Acad. Sci. U. S. A. 2021, 118, e2102310118.(Cai and Hua contributed equally to this work.)
65. Zhang, H.;* Novak, A. J. E.; Jamieson, C. S.; Xue, X. S.; Chen, S.; Trauner, D.;* Houk, K. N.* Computational Exploration of the Mechanism of Critical Steps in the Biomimetic Synthesis of Preuisolactone A, and Discovery of New Ambimodal (5 + 2)/(4 + 2) Cycloadditions. J. Am. Chem. Soc. 2021, 143, 6601-6608.
64. Luo, M.;† Cai, Y.;† Lin, X.; Long, L.; Zhang, H.;* Xia, H.* Synthesis, Characterization and Reactivity of Metalla-chalcogenirenium Compounds. Chin. J. Chem. 2021, 39, 1558-1564.(Luo and Cai contributed equally to this work.)
63 .Zhang, J.-X.;† Sheong, F. K.;† Lu, Z.; Zhang, H.;* Lin, Z.* Unexpected Electronic Behavior of Organic Azide and Metal‐Carbyne in Their 1,3‐Dipolar Cycloaddition Reaction. Chin. J. Chem. 2020, 38, 1565-1570.(Zhang and Sheong contributed equally to this work.)
62. Huang, F.; Zheng, X.; Lin, X.; Ding, L.; Zhuo, Q.; Wen, T. B.; Zhang, H.;* Xia, H.* Extension of the Simmons–Smith Reaction to Metal-carbynes: Efficient Synthesis of Metallacyclopropenes with σ-Aromaticity. Chem. Sci. 2020, 11, 10159-10166.
61. Deng, Z.;† Wu, P.;† Cai, Y.; Sui, Y.; Chen, Z.; Zhang, H.; Wang, B.;* Xia, H.* Dioxygen Activation by Internally Aromatic Metallacycle: Crystallographic Structure and Mechanistic Investigations. iScience 2020, 23, 101379. (Deng and Wu contributed equally to this work.)
60. Lin, J.; Xu, Q.; Lin, X.; Hua, Y.; Chen, D.; Ruan, Y.; Zhang, H.;* Xia, H.* The First OCCCO Pentadentate Chelates: Osmium Mediated Stepwise Oxidations of Terminal Alkynes by Pyridine N‐Oxide. Chin. J. Chem. 2020, 38, 1273-1279.
59. Luo, M.; Hua, Y.; Zhuo, K.; Long, L.; Lin, X.; Deng, Z.; Lin, Z.; Zhang, H.; Chen, D.; Xia, H.* Carbolong Chemistry: Planar CCCCX-Type (X = N, O, S) Pentadentate Chelates by Formal [3+1] Cycloadditions of Metalla-Azirines with Terminal Alkynes. CCS Chemistry 2020, 2, 758-763.
58. Luo, M.; Sui, Y.; Lin, X.; Zhu, C.; Yan, Z.; Ruan, Y.; Zhang, H.;* Xia, H.* [3+2] Cycloaddition Reaction of Metallacyclopropene with Nitrosonium Ion: Isolation of Aromatic Metallaisoxazole. Chem. Commun. 2020, 56, 6806 - 6809.
57. Ni, D.; Witherspoon, B. P.; Zhang, H.; Zhou, C.; Houk, K. N.;* Brown, M. K.* Stereoselective [4+2]-Cycloaddition with Chiral Alkenylboranes. Angew. Chem., Int. Ed. 2020, 59, 11432-11439.
56. Lu, Z.;† Zhu, Q.;† Cai, Y.; Chen, Z.; Zhuo, K.; Zhu, J.; Zhang, H.;* Xia, H.* Access to Tetracyclic Aromatics with Bridgehead Metals via Metalla-click Reactions. Sci. Adv. 2020, 6, eaay2535.(Lu and Zhu contributed equally to this work.)
55. Zhuo, Q.;† Zhang, H.;† Ding, L.; Lin, J.; Zhou, X.; Hua, Y.; Zhu, J.; Xia, H.* Rhodapentalenes: Pincer Complexes with Internal Aromaticity. iScience 2019, 19, 1214-1224.(Zhuo and Zhang contributed equally to this work.)
54. Luo, M.; Deng, Z.; Ruan, Y.; Cai, Y.; Zhuo, K.; Zhang, H.;* Xia, H. Reactions of Metallacyclopentadiene with Terminal Alkynes: Isolation and Characterization of Metallafulvenallene Complexes. Organometallics 2019, 38, 3053-3059.(ACS Editors’ Choice)
53. Lin, J.; Ding, L.; Zhuo, Q.; Zhang, H.;* Xia, H.* Formal [2+2+2] Cycloaddition Reaction of a Metal–Carbyne Complex with Nitriles: Synthesis of a Metallapyrazine Complex. Organometallics 2019, 25, 5077-5085.
52. Zhou, X.; Pang, X.; Nie, L.; Zhu, C.; Zhuo, K.; Zhuo, Q.; Chen, Z.; Liu, G.; Zhang, H.;* Lin, Z.; Xia, H. Successive Modification of Polydentate Complexes Gives Access to Planar Carbon- and Nitrogen-based Ligands. Nat. Commun. 2019, 10, 1488.
51. Li, J.; Lin, Y. M.;* Zhang, H.; Chen, Y.; Lin, Z.; Xia, H.* Access to Metal-Bridged Osmathiazine Derivatives by a Formal [4+2] Cyclization. Chem. - Eur. J. 2019, 25, 5077-5085.
50. Li, J.; Kang, H.; Zhuo, K.; Zhuo, Q.; Zhang, H.; Lin, Y.-M.;* Xia, H.* Alternation of Metal-Bridged Metallacycle Skeletons: From Ruthenapentalyne to Ruthenapentalene and Ruthenaindene Derivative. Chin. J. Chem. 2018, 36, 1156-1160.
49. Zhuo, Q.;† Zhang, H.;† Hua, Y.; Kang, H.; Zhou, X.; Lin, X.; Chen, Z.; Lin, J.; Zhuo, K.; Xia, H.* Constraint of a Ruthenium-Carbon Triple Bond to a Five-Membered Ring. Sci. Adv. 2018, 4 (6), eaat0336.(†Zhuo and Zhang contributed equally to this work.)
48. Zhou, X.; Li, Y.; Shao, Y.; Hua, Y.; Zhang, H.; Lin, Y.-M.;* Xia, H.* Reactions of Cyclic Osmacarbyne with Coinage Metal Complexes. Organometallics 2018, 37, 1788-1794.
47. Zhou, X.; Huang, F.; Tang, C.; Zhuo, Q.; Chen, Z.; Zhang, H.;* Xia, H. A Missing Member of Conjugated N-Heterocycles: Realizing Pyrido[1,2-Α]azepine by Reacting Ruthenium Alkenylcarbene Complex with Alkyne. Chem. Commun. 2018, 54, 4009-4012.
46. Zhou, X.; Zhang, H.* Reactions of Metal-Carbon Bonds within Six-Membered Metallaaromatic Rings. Chem. - Eur. J. 2018, 24, 8962-8973.
45. Hua, Y.; Zhang, H.;* Xia, H.* Aromaticity: History and Development. Chin. J. Org. Chem. 2018, 38, 11-28.
44. Zhuo, Q.; Lin, J.; Hua, Y.; Zhou, X.; Shao, Y.; Chen, S.; Chen, Z.; Zhu, J.; Zhang, H.; Xia, H.* Multiyne Chains Chelating Osmium via Three Metalcarbon σ Bonds. Nat. Commun. 2017, 8, 1912.
43. Long, L.; Zhou, X.; Wang, T.; Chen, Z.; Zhang, H.;* Xia, H.* Synthesis of Imidazopyridinium-Fused Metallacycloallene via One-Pot Reaction of η2-Alkynol-Coordinated Osmacycle with 2-Aminopyridine. Organometallics 2017, 36, 4184−4190.
42. Huang, Z.-A.; Lan, Q.; Hua, Y.; Chen, Z.; Zhang, H.;* Lin, Z.; Xia, H. Color-Tuning Strategy for Iridapolycycles [(N∧N)Ir(C∧C)ClPPh3]+ by the Synergistic Modifications on Both the C∧C and N∧N Units. Organometallics 2017, 36, 4802–4809.
41. Luo, M.; Long, L.; Zhang, H.;* Yang, Y.; Hua, Y.; Liu, G.; Lin, Z.;* Xia, H.* Reactions of Isocyanides with Metal Carbyne Complexes: Isolation and Characterization of Metallacyclopropenimine Intermediates. J. Am. Chem. Soc. 2017,139, 1822-1825.
40. Chen, J.;† Huang, Z.-A.;† Lu, Z.; Zhang, H.;* Xia, H.* Synthesis of Cyclic Vinylidene Complexes and Azavinylidene Complexes by Formal [4+2] Cyclization Reactions. Chem. - Eur. J. 2016, 22, 5363-5375.(†Chen and Huang contributed equally to this work.)
39. Zhuo, Q.; Zhou, X.; Kang, H.; Chen, Z.; Yang, Y.; Han, F.; Zhang, H.;* Xia, H.* Synthesis of Fused Metallaaromatics via Intramolecular C−H Activation of Thiophenes. Organometallics 2016, 35, 1497-1504.
38. Zhuo, Q.;† Chen, Z.;† Yang, Y.; Zhou, X.; Han, F.; Zhu, J.; Zhang, H.;* Xia, H.* Synthesis of Aromatic Ruthenabenzothiophenes via C–H Activation of Thiophenes. Dalton Trans. 2016, 45, 913-917.(†Zhuo and Chen contributed equally to this work.)
37. Luo, M.; Zhu, C.; Chen, L.; Zhang, H.;* Xia, H.* Halogenation of Carbyne Complexes: Isolation of Unsaturated Metallaiodirenium Ion and Metallabromirenium Ion. Chem. Sci. 2016, 7, 1815-1818.
36. Zhou, X.; He, X.; Lin, J.; Zhuo, Q.; Chen, Z.; Zhang, H.;* Wang, J.;* Xia, H.* Reactions of Osmium Hydrido Alkenylcarbyne with Allenoates: Insertion and [3 + 2] Annulation. Organometallics 2015, 34, 1742-1750.
35. Wei, Y.; Zhou, X.; Hong, G.; Chen, Z.; Zhang, H.;* Xia, H.* Reactions of Osmapyridinium with Terminal Alkynes. Org. Chem. Front. 2015, 2, 560-568.
34. Chen, J.; Huang, Z.-A.; Hua, Y.; Zhang, H.;* Xia, H. Synthesis of Five-Membered Osmacycles with Osmium–Vinyl Bonds from Hydrido Alkenylcarbyne Complexes. Organometallics 2015, 34, 340-347.
33. Wang, T.; Han, F.; Huang, H.; Li, J.; Zhang, H.;* Zhu, J.; Lin, Z.;* Xia, H.* Synthesis of Aromatic Aza-metallapentalenes from Metallabenzene via Sequential Ring Contraction/Annulation. Sci. Rep. 2015, 5, 9584.
32. Han, F.; Li, J.; Zhang, H.;* Wang, T.; Lin, Z.;* Xia, H.* Reactions of Osmabenzene with Silver/Copper Acetylides: From Metallabenzene to Benzene. Chem. - Eur. J. 2015, 21, 565-567.
31. Chen, J.;† Huang, Z.-A.;† Hua, Y.; Zhang, H.;* Xia, H. Synthesis of Five-Membered Osmacycles with Osmium–Vinyl Bonds from Hydrido Alkenylcarbyne Complexes. Organometallics 2015, 34, 340-347.(†Chen and Huang contributed equally to this work.)
30. Han, F.; Wang, T.; Li, J.; Zhang, H.;* Xia, H.* m-Metallaphenol: Synthesis and Reactivity Studies. Chem. - Eur. J. 2014, 20, 4363-4372.
29. Zhang, H.;* Lin, R.; Li, J.; Xia, H. Interconversion between Ruthenacyclohexadiene and Ruthenabenzene: A Combined Experimental and Theoretical Study. Organometallics 2014, 33, 5606-5609.
28. Zhuo, Q.; Wang T.; Zhou, X.; Zhang, H.* Progresses of Ring Expansion Reaction of Small Transitional Metallacyclic Compounds. Chin. J. Org. Chem. 2014, 34, 1471-1486.
27. Han, F.; Wang, T.; Li, J.; Zhang, H.; Zhang; L.; He, X.;* Xia, H.* Synthesis, Structure, and Reactivity of an Osmacyclopentene Complex. Organometallics 2014, 33, 5301-5307.
26. Wang, T.; Zhu, J.; Han, F.; Zhou, C.; Chen, H.; Zhang, H.;* Xia, H.* Synthesis of Five-membered Osmacycloallenes and Conversion to Six-membered Osmacycloallenes. Angew. Chem., Int. Ed. 2013, 52, 13361-13364.
25. Wang, T.;† Zhang, H.;† Han, F.; Long, L.; Lin, Z.;* Xia, H.* Key Intermediates of Iodine-Mediated Electrophilic Cyclization: Isolation and Characterization. Angew. Chem., Int. Ed. 2013, 52, 9251-9255. (†Wang and Zhang contributed equally to this work.)
24. Wang, T.;† Zhang, H.;† Han, F.; Long, L.; Lin, Z.;* Xia, H.* cine-Substitution Reactions of Metallabenzenes: An Experimental and Computational Study. Chem. - Eur. J. 2013, 19, 10982-10991. (†Wang and Zhang contributed equally to this work.)
23. Chen, J.; Zhang, C.; Xie, T.; Wen, T. B.; Zhang, H.;* Xia, H. Conversion of a Hydrido–Butenylcarbyne Complex to η2-Allene-Coordinated Complexes and Metallabenzenes. Organometallics 2013, 32, 3993-4001.
22. Zhang, C.; Zhang, H.; Zhang, L.; Wen, T. B.; He, X.;* Xia, H.* Mechanistic Study of Indolizine Heterocycle Formation by Ruthenium(II)-Assisted Three-Component Cross-Coupling/Cyclization. Organometallics 2013, 32, 3738-3743.
21. Zhang, C.; Zhang, H.; Wei, A.; He, X.;* Xia, H.* Synthesis of Ruthena-polycyclic Complexes by Ruthenium-Vinylcarbene Complex. Acta Chim. Sinica 2013, 71, 1373.
20. Xie, H.; Zhang, H.; Lin, Z.* DFT Studies on the Palladium-Catalyzed Dearomatization Reaction between Chloromethylnaphthalene and the Cyclic Amine Morpholine. Organometallics 2013, 32, 2336-2343.
19. Xie, H.; Zhang, H.; Lin, Z.* DFT Studies on the Mechanisms of Palladium-Catalyzed Intramolecular Arylation of a Silyl C(sp3)–H Bond. New J. Chem. 2013, 37, 2856-2861.
18. Wang, T.;† Zhang, H.;† Han, F.; Long, L.; Lin, Z.;* Xia, H.* Synthesis and Characterization of a Metallapyridyne Complex. Angew. Chem., Int. Ed. 2012, 51, 9838–9841. (†Wang and Zhang contributed equally to this work.)
17. Lin, R.; Zhao, J.; Chen, H.; Zhang, H.;* Xia, H.* Interconversion of Metallabenzenes and Cyclic η2-Allene-Coordinated Complexes. Chem. - Asian J. 2012, 7, 1915–1924.
16. Lin, R.; Zhang, H.;* Li, S.; Wang, J.; Xia, H.* New Highly Stable Metallabenzenes via Nucleophilic Aromatic Substitution Reaction. Chem. - Eur. J. 2011, 17, 4223–4231. (Inside Cover)
15. Lin, R.; Zhang, H.;* Cao, X.-Y.; Xia, H. The Electrophilic Aromatic Addition and Substitution Reactions of Metallabenzenes. Journal of Xiamen University(Natural Science) 2011, 50 (S1), 1-4.
14. Lin, R.; Zhang, H.; Li, S.*; Chen, L.; Zhang, W.; Wen, T. B.; Zhang, H.;* Xia, H.* pH-Switchable Inversion of the Metal-Centered Chirality of Metallabenzenes: Opposite Stereodynamics in Reactions of Ruthenabenzene with l- and d-Cysteine. Chem. - Eur. J. 2011, 17, 2420-2427.(This article has been highlighted by ACS "Noteworthy Chemistry".)
13. Zhang, H.;* Lin, R.; Luo, M.; Xia, H.* Synthesis and Characterization of Stable Osmafuran Starting from HC≡CCH(OH)C≡CH and OsHCl(CO)(PPh3)3, Sci. China: Chem. 2010, 53, 1978-1981.
12. Zhang, H.;* Lin, R.; Hong, G.; Wang, T.; Wen, T. B.; Xia, H.* Nucleophilic Aromatic Addition Reactions of the Metallabenzenes and Metallapyridinium: Attacking Aromatic Metallacycles with Bis(diphenylphosphino)methane to Form Metallacyclohexadienes and Cyclic η2-Allene-Coordinated Complexes. Chem. - Eur. J. 2010, 16, 6999-7007.
11. Wang, T. ; Li, S.; Zhang H.; Lin R.; Han F.; Lin Y.; Wen T. B.; Xia, H.* Annulation of Metallabenzenes: From Osmabenzene to Osmabenzothiazole to Osmabenzoxazole. Angew. Chem., Int. Ed. 2009, 48, 6453-6456.
10. Zhang, H.; Wu, L.; Lin, R.; Zhao, Q.; He, G.; Yang, F.; Wen, T. B.; Xia, H.* Synthesis, Characterization and Electrochemical Properties of Stable Osmabenzenes Containing PPh3 Substituents. Chem. - Eur. J. 2009, 15, 3546-3559.
9. Wu, L.; Feng, L.; Zhang, H.; Liu, Q.; He, X.; Yang, F.; Xia, H.* Synthesis and Characterization of a Novel Dialdehyde and Cyclic Anhydride. J. Org. Chem. 2008, 73, 2883–2885.
8. Gong, L.; Lin, Y.; Wen, T. B.; Zhang, H.; Zeng, B.; Xia, H.* Formation of Four Conjugated Osmacyclic Species in a One-Pot Reaction. Organometallics 2008, 27, 2584–2589.
7. Gong, L.; Lin, Y.; He, G.; Zhang, H.; Wang, H.; Wen, T. B.;* Xia, H.* Synthesis and Characterization of an Air-Stable p-Osmaphenol. Organometallics 2008, 27, 309–311.
6. Zhang, H.; Feng, L.; Gong, L.; Wu, L.; He, G.; Wen, T. B.; Yang, F.; Xia, H.* Synthesis and Characterization of Stable Ruthenabenzenes Starting from HC≡CCH(OH)C≡CH. Organometallics 2007, 26, 2705-2713.
5. Gong, L.; Wu, L.; Lin, Y.; Zhang, H.; Yang, F.; Wen, T.; Xia, H.* Synthesis and Characterization of a Bimetallic Iridium Complex with a Ten sp2-Carbon Chain Bridge. Dalton Trans. 2007, 4122-4125.
4. Zhang, H.; Xia, H.;* He, G.; Wen, T. B.; Jia, G.* Synthesis and Characterization of Stable Ruthenabenzenes. Angew. Chem., Int. Ed. 2006, 45, 2920-2923.(VIP).（This article has been highlighted by ACS "Heart Cut".）
3. Xia, H.;* He, G.; Zhang, H.; Wen, T. B.; Sung, H. H. Y.; Williams, I. D.; Jia, G.* Osmabenzenes from the Reactions of HC≡CCH(OH)C≡CH with OsX2(PPh3)3 (X = Cl, Br). J. Am. Chem. Soc. 2004, 126, 6862-6863.（This article has been highlighted by ACS "Chemical & Engineering News". ）
2. Zhang, H.; He, G.; Xia, H.* Progress of Study on Linear Carbon Bridged Organometallic Molecular Wires. Chin. J. Org. Chem. 2004, 24, 355-365.
1. Zhang, H.; He, X.;* Ding, M. Application of Pessure-Driven Membrane in Meallurgical Industry. Journal of Functional Materials (Chinese) 2002, 33, 588-569, 593.